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Infectious disease

As a virus-infected model, the utilization of tonsil, adenoid, and lung organoids allows for the evaluation of antiviral drug efficacy and facilitates virus research.

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Infectious disease

This model allows researchers to study the dynamics of viral entry, replication, and host response within the tonsil organoid system.
Lambda provides a comprehensive solution, offering the service of applying antiviral treatments such as Remdesivir.
This allows for an investigation into their therapeutic efficacy in reducing viral replication.

Cell Type

· ASC

Organoid type

· Tonsil organoid

This model allows researchers to study the dynamics of viral entry, replication, and host response within the adenoid organoid system.
Lambda provides a comprehensive solution, offering the service of applying antiviral treatments.
This allows for an investigation into their therapeutic efficacy in reducing viral replication.

Cell Type

· ASC

Organoid type

· Adenoid organoid

Lung organoids, mimicking the human lung, are instrumental in respiratory infection research.
Lambda specifically employs patient-derived lung organoids for assessing the effectiveness of antiviral drugs.
This approach enhances our understanding of disease pathogenesis, aids in drug discovery, contributes to vaccine development, and provides a physiologically relevant platform for studying host-pathogen interactions.

Cell Type

· ASC

Organoid type

· Lung organoid

Assay

SARS-COV-2 infection model (Adenoid organoid)

The SARS-CoV-2 infection model using adenoid organoids involves exposing the organoids to the virus to simulate infection conditions.
This model allows researchers to study the dynamics of viral entry, replication, and host response within the adenoid organoid system.
Lambda provides a comprehensive solution, offering the service of applying antiviral treatments.
This allows for an investigation into their therapeutic efficacy in reducing viral replication.

Assay process

  • Step 1: Production and cultivation of adenoid organoids from adenoid tissue.
  • Step 2: Infection of adenoid organoids with SARS-CoV-2, and determination of viral titer through plaque assay.
  • Step 3: Treatment of SARS-CoV-2 infected adenoid organoids.
  • Step 4: After treating the infected tonsil organoid with an antiviral drug, evaluate the efficacy of the antiviral drug by measuring the virus concentration in the organoid and checking the remaining virus.

Technical

SARS-CoV-2 Infection data (H&E/IF)

In H&E and IF, the phenomenon of virus infection within the nucleus was discovered (experimental conditions: MOCK, adV 10-3)

SARS-CoV-2 Infection data (Titration/TEM)

Virus titration confirms that virus replication occurs during virus infection. Virus infection is confirmed using an electron microscope.