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Efficient Hepatocyte Differentiation of Primary Human Hepatocyte-Derived Organoids Using Three Dimensional Nanofibers (HYDROX) and Their Possible Application in Hepatotoxicity Research

Efficient Hepatocyte Differentiation of Primary Human Hepatocyte-Derived Organoids Using Three Dimensional Nanofibers (HYDROX) and Their Possible Application in Hepatotoxicity Research Human liver organoids, which are 3D cultured cells with stem cell characteristics, have shown promise in drug discovery but are limited by their lower hepatic function compared to primary human hepatocytes (PHHs). Efforts to enhance […]

Designer Immune-cell Therapy Could Shrink Deadly Brain Tumors

Designer Immune-cell Therapy Could Shrink Deadly Brain Tumors Two early clinical trials have shown promising results for a new immune cell-based treatment called CAR-T therapy in treating glioblastoma, the most aggressive form of brain cancer. This therapy involves genetically modifying patients’ immune cells, known as T cells, to better recognize and attack tumors. Both trials, […]

Major AlphaFold Upgrade Offers Boost for Drug Discovery

Major AlphaFold Upgrade Offers Boost for Drug Discovery Since the release of AlphaFold2 in 2021, scientists have leveraged its advanced protein structure prediction capabilities for diverse applications, including mapping cellular machinery, drug discovery, and protein universe exploration. Despite its successes, John Jumper, the leader of AlphaFold’s development at Google DeepMind, faced inquiries about expanding the […]

First Model of the Brain’s Information Highways Developed

First Model of the Brain’s Information Highways Developed Researchers at IMBA, including Catarina Martins-Costa, Nina Corsini, and Jürgen Knoblich, have developed a groundbreaking organoid model of the human brain’s long-range nerve bundles, akin to its information highways. Published in Cell Stem Cell on May 7th, their study focuses on the corpus callosum, a vital bridge […]

AI Traces Mysterious Metastatic Cancers to Their Source

AI Traces Mysterious Metastatic Cancers to Their Source Cancer of unknown primary (CUP) presents a challenge due to its poor prognosis and difficulty in determining the primary tumor site. Despite being heterogeneous, with metastases to various organs, diagnosing CUP is crucial for treatment. An artificial intelligence (AI) tool, TORCH, has been developed to assist pathologists […]

Antibody Therapy Makes the Immune Systems of Old Mice Young Again

Antibody Therapy Makes the Immune Systems of Old Mice Young Again A promising antibody therapy rejuvenates the immune system of older mice, enhancing their ability to combat infections and reduce inflammation. This treatment could potentially reverse age-related declines in human immunity, addressing susceptibility to disease in older adults. Age-related immune decline is linked to changes […]

Heterozygous RB1 Mutation Enhanced ATP Production in Human iPSC-Derived Retinal Organoids

Heterozygous RB1 Mutation Enhanced ATP Production in Human iPSC-Derived Retinal Organoids Recent in vitro studies have shown molecular and functional disruptions in RB1 gene heterozygous (RB1+/−) fibroblasts and mesenchymal stem cells (MSCs), even without biallelic loss of RB1. However, this was not observed in RB1+/− retinal organoids. To understand these differences, researchers conducted high-throughput RNA […]

Synergistic Hyperactivation of Both mTORC1 and mTORC2 Underlies the Neural Abnormalities of PTEN-deficient Human Neurons and Cortical Organoids

Synergistic Hyperactivation of Both mTORC1 and mTORC2 Underlies the Neural Abnormalities of PTEN-deficient Human Neurons and Cortical Organoids Mutations in the PTEN gene are linked to severe neurodevelopmental disorders. This study demonstrates that loss of PTEN results in the hyperactivation of two protein complexes, mTORC1 and mTORC2, leading to various disease-relevant phenotypes in human neurons, […]

Hyaluronan Improves Photoreceptor Differentiation and Maturation in Human Retinal Organoids

Hyaluronan Improves Photoreceptor Differentiation and Maturation in Human Retinal Organoids This study explores the potential of hyaluronan (HA), a component of the interphotoreceptor matrix, in promoting long-term survival and enhancing maturation of human retinal organoids, which are valuable for disease modeling and cell transplantation. HA treatment reduces cell proliferation and increases photoreceptor commitment, leading to […]

High-Fat Diet Enhances Cell Proliferation and Compromises Intestinal Permeability in a Translational Canine Intestinal Organoid Model

High-Fat Diet Enhances Cell Proliferation and Compromises Intestinal Permeability in a Translational Canine Intestinal Organoid Model This study explores how the mammalian intestine responds to dietary cues, particularly through LGR5+ intestinal stem cells, and investigates the effects of high-fat diets (HFDs) on cellular dynamics and gut integrity. Using a canine colonoid model, the interactions between […]