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Revolutionizing Medical Research: The Rise of AI-Enabled Organoids

Revolutionizing Medical Research: The Rise of AI-Enabled Organoids Innovations at the Intersection of AI and Biomedical Science The convergence of artificial intelligence (AI) and organoid technology marks a revolutionary step forward in the field of biomedical research and therapeutic development. Organoids, three-dimensional structures derived from stem cells that mimic real human organs, are now being […]

Designer Immune-cell Therapy Could Shrink Deadly Brain Tumors

Designer Immune-cell Therapy Could Shrink Deadly Brain Tumors Two early clinical trials have shown promising results for a new immune cell-based treatment called CAR-T therapy in treating glioblastoma, the most aggressive form of brain cancer. This therapy involves genetically modifying patients’ immune cells, known as T cells, to better recognize and attack tumors. Both trials, […]

Major AlphaFold Upgrade Offers Boost for Drug Discovery

Major AlphaFold Upgrade Offers Boost for Drug Discovery Since the release of AlphaFold2 in 2021, scientists have leveraged its advanced protein structure prediction capabilities for diverse applications, including mapping cellular machinery, drug discovery, and protein universe exploration. Despite its successes, John Jumper, the leader of AlphaFold’s development at Google DeepMind, faced inquiries about expanding the […]

AI Traces Mysterious Metastatic Cancers to Their Source

AI Traces Mysterious Metastatic Cancers to Their Source Cancer of unknown primary (CUP) presents a challenge due to its poor prognosis and difficulty in determining the primary tumor site. Despite being heterogeneous, with metastases to various organs, diagnosing CUP is crucial for treatment. An artificial intelligence (AI) tool, TORCH, has been developed to assist pathologists […]

Antibody Therapy Makes the Immune Systems of Old Mice Young Again

Antibody Therapy Makes the Immune Systems of Old Mice Young Again A promising antibody therapy rejuvenates the immune system of older mice, enhancing their ability to combat infections and reduce inflammation. This treatment could potentially reverse age-related declines in human immunity, addressing susceptibility to disease in older adults. Age-related immune decline is linked to changes […]

Sebaceous Gland Organoid Engineering

Sebaceous Gland Organoid Engineering This review discusses the importance of sebaceous glands (SGs) in skin lubrication and barrier function, highlighting their loss in large skin defects and the lack of effective regeneration strategies. It introduces organoids as promising tools in regenerative medicine, detailing recent advancements in SG organoid development that replicate in vivo characteristics. The […]

Brain Organoid + Computer = ?

Brain Organoid + Computer = ? Organoid Intelligence (OI): The New Frontier in Biocomputing and Intelligence-in-a-Dish What is organoid intelligence (OI)? Introduction to the concept of organoid intelligence (OI): This research explores the potential of biological computing using brain organoids derived from human stem cells. The term “organoid intelligence” is used to describe the potential […]

Organoids: Today’s Research Tool, Tomorrow’s Organ Transplant Solution

Organoids: Today’s Research Tool, Tomorrow’s Organ Transplant Solution The article discusses the potential of organoids in personalized medicine and regenerative therapies. Organoids, derived from an individual’s cells, offer a way to tailor treatments to patient needs by screening compounds and understanding patient-specific responses to drugs. Researchers, like Mingxia Gu at Cincinnati Children’s, are utilizing organoids […]

Newly Developed Organoid Model Can be Used to Study Thymus Function

Newly Developed Organoid Model Can be Used to Study Thymus Function Researchers have developed a new organoid model to study the thymus, a crucial organ for training T cells of the immune system. These organoids, derived from mouse thymus tissue, specifically mimic thymic epithelial cells (TECs), which play a vital role in T cell training. […]

AI Tool Creates ‘Synthetic’ Images of Cells for Enhanced Microscopy Analysis

AI Tool Creates ‘Synthetic’ Images of Cells for Enhanced Microscopy Analysis UC Santa Cruz researchers have developed a novel method to address the challenge of limited annotated data for training artificial intelligence (AI) models in single-cell segmentation. Their approach involves using a microscopy image generation AI model to create realistic images of single cells, termed […]