WNT Signaling Drives Human Urothelial Organoid Development
Journal: iScience
Author: Na Qu et al., USA
Researchers developed human urothelial organoids from pluripotent stem cells by manipulating WNT signaling, offering a powerful model for studying developmental pathways in human urothelium
Engineered Microglia Enable Brain-Wide Therapeutic Protein Delivery
Journal: Cell Stem Cell
Author: Jean Paul Chadarevian et al., USA
CRISPR-edited human iPSC-microglia deliver Aβ-degrading enzymes throughout the brain, reducing pathology in Alzheimer’s and showing promise for treating diverse CNS disorders.
Mapping Melanocyte Development Using Pluripotent Stem Cells
Journal: iScience
Author: Jie Yang et al., China
Single-cell sequencing reveals signaling pathways and markers in melanocyte development from pluripotent stem cells, providing insights for pigment-related disease therapies.
Bifidobacterium Vesicles Enhance Immunotherapy in Lung Cancer
Journal: Nature Communications
Author: Ranjan Preet et al., USA
Gut bacteria-derived vesicles travel to lung tumors, modulate the microenvironment, and synergize with anti-PD-1 therapy, revealing new mechanisms of gut-tumor communication.
