GBOs Mirror Patient CAR-T Cell Responses in Real-Time Clinical Trial
Journal: Cell
Author: Logun M., Wang X. et al., USA
Researchers used patient-derived glioblastoma organoids (GBOs) alongside a phase 1 CAR-T cell trial, finding that organoid responses – including target antigen reduction, tumor lysis. and cytokine patterns – accurately predicted patient outcomes in cerebrospinal fluid, establishing GBOs as a valuable real-time bioactivity assessment platform for immunotherapy.
Gene Editing Creates Malaria-Resistant Mosquito Populations
Journal: Nature
Author: Li Z., Dong Y. et al., USA
Scientists developed a gene editing system that spreads the natural FREP1Q224 allele through Anopheles stephensi mosquitoes, making them highly resistant to malaria parasites while minimally affecting their survival in the wild – offering a promising genetic tool for malaria elimination efforts.
USP5 Enzyme Key Regulator of Mast Cell Allergic Responses
Journal: Science
Author: Zhou Z., Xu X. et al., China
Researchers discovered that USP5 enzyme stabilizes FcεRIγ receptor in mast cells by preventing its degradation. Blocking USP5 reduced allergic inflammation in mice, identifying USP5 as a promising therapeutic target for IgE-mediated allergic diseases.
COVID-19 Pandemic Accelerated Brain Aging by 5.5 Months
Journal: Nature Communications
Author: Mohammadi-Nejad A., Craig M. et al., UK
UK Biobank study of 996 participants found the pandemic accelerated brain aging by 5.5 months on average, particularly affecting males and socioeconomically disadvantaged groups, highlighting broader pandemic health impacts.
