Human iPSC-derived heart valve-like assembloids model valve development and disease pathology
Journal: Cell Stem Cell
Author: Yuanhang He et al., China
Human iPSC-derived valve assembloids recreate fetal valve features and reveal how mechanical forces, endothelial cues, and shear stress shape development and disease.
Rb-driven transcription limits its tumour-suppressive effects in breast cancer
Journal: Nature
Author: April C. Watt, Antonio Ahn et al., Australia
Activated Rb suppresses cell-cycle genes but also boosts estrogen-responsive transcription, helping explain CDK4/6 inhibitor synergy and resistance in hormone receptor-positive breast cancer.
H3K18 lactylation drives CD8+ T cell exclusion and anti-PD-1 resistance in hepatocellular carcinoma
Journal: Cell
Author: Jiang Zhu, Xinye Dai et al., China
In hepatocellular carcinoma, H3K18 lactylation drives CD8+ T-cell exclusion and anti-PD-1 resistance through TRPS1/GLUT1 and ETV1/CCL2, revealing actionable therapeutic targets.
Intratumoral Bacillus cereus orchestrates stem-like lymphoid niches to potentiate immunotherapy response in hepatocellular carcinoma
Journal: Cancer Cell
Author: Chupeng Hu, Wenhua You et al., China
Intratumoral Bacillus cereus promotes stem-like lymphoid niches that enhance checkpoint immunotherapy responses in hepatocellular carcinoma through endothelial IL-33 and ILC2–Tpex remodeling.
