Evolution of myeloid-mediated immunotherapy resistance in prostate cancer
Journal: Nature
Author: Aram Lyu, USA
The research identifies SPP1hi-TAMs as crucial mediators of immunotherapy resistance in advanced prostate cancer (mCRPC), demonstrating that targeting adenosine signaling can enhance treatment effectiveness.
RANK drives structured intestinal epithelial expansion during pregnancy
Journal: Nature
Author: Masahiro Onji, Austria
This study identifies the RANK-RANKL signaling pathway as a key driver of intestinal epithelial expansion during pregnancy/lactation in mammals, representing a fundamental tissue remodeling mechanism that impacts maternal and offspring health.
Beyond classical immunity: Mast cells as signal converters between tissues and neurons
Journal: Cellpress
Author: Thomas Plum, Germany
This study reveals that mast cells not only function in immune defense but also act as ‘signal converters’ that regulate sensations like pain, itch, and nausea from tissue damage and inflammation, linking immune states with nervous system responses.
Short-chain fatty acids and cancer
Journal: Cellpress
Author: Shan Li, China
Short chain fatty acids (SCFAs) influence cancer cells through multiple mechanisms including energy sources, G protein-coupled receptor signaling, and histone deacetylase inhibition, linking diet and metabolism to epigenetic regulation, showing potential for cancer prevention and treatment.
