Vascular Organoids Generated in Five Days Transform Regenerative Medicine
Journal: Nature Genetics
Author: Maria Letizia Di Martino et. al, Sweden
Scientists create functional vascular organoids from stem cells in just 5 days using transcription factor activation, achieving successful engraftment and revascularisation in animal models.
Lung Cancer Organoids Predict Patient Response to Immunotherapy with Precision
Journal: Cell Stem Cell
Author: Kaiyi Li et. al, China
Novel gel-liquid interface co-culture system combining lung cancer organoids with immune cells accurately predicts immunotherapy outcomes, identifying new biomarkers for treatment efficacy.
Human Gut Organoids Reveal Complete Genetic Map of Bacterial Infection Mechanisms
Journal: Cell Stem Cell
Author: Liyan Gong et. al, USA
Large-scale intestinal organoid infections combined with advanced genomics unveil comprehensive genetic circuits driving Shigella pathogenesis, revealing novel therapeutic targets.
Engineered CAR-T Regulatory Cells Show Enhanced Immune Suppression Capabilities
Journal: Science Advances
Author: Dominic A. Boardman et. al, Canada
CRISPR-modified CAR Treg cells with IL-10 expression demonstrate superior suppressive function in controlling autoimmune responses and preventing graft rejection in preclinical studies.
