Multi-Species Bat Organoid Platform Revolutionizes Zoonotic Virus Research
Journal: Science
Author: Hyunjoon Kim et al. South Korea
Researchers developed organoidsfrom five bat species and four organ types, creating robust models that reveal species-specific virus replication patterns, enabling pathogen surveillance and antiviral drug testing for zoonotic diseases.
Sox11 Identified as Key Regulator in Colorectal Cancer Invasion Process
Journal: Oncogenesis
Author: Yu-Hsiang Teng et al., Germany
Using intestinal organoids with CRC mutations, researchers discovered Sox11’s dual role in normal gut function and TGF-β1-induced partial EMT, revealing mechanisms behind collective tumor invasion and identifying poor prognosis markers.
Spatial Multi-Omics Maps Metabolic Landscape of Pancreatic Cancer Microenvironment
Journal: iScience
Author: Hao Wu et al., China
Integrated spatial transcriptomics and metabolomics reveal metabolic heterogeneity in pancreatic cancer, identifying signature metabolic alterations and aberrant cell communications between cancer cells, macrophages, and fibroblasts.
Single-Cut CRISPR Shows Promise for Duchenne Muscular Dystrophy Treatment
Journal: Molecular Therapy
Author: Mateusz Z. Durbacz et al., USA
Researchers used single-cut CRISPR gene editing to restore dystrophin protein expression in DMD patient cells and humanized mice, successfully improving muscle function and reducing disease symptoms through AAV9 delivery.
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