Morphogen-guided neocortical organoids with anteroposterior areal identity
Journal: Cell Stem Cell
Author: Yuan-Chen Tsai, Hajime Ozaki et al., USA
Morphogen-guided organoids recreate human cortical regional patterning, revealing how disrupted anteroposterior identity may contribute to neurodevelopmental disorders.
A CRISPR-based ‘dam-break drainage’ sensing architecture for rapid, affordable and ultrasensitive pathogen detection
Journal: Nature Communications
Author: Kai Liu, Xiang Li et al., China
A CRISPR-Cas13a chip turns viral detection into a simple visual signal, enabling ultrasensitive, low-cost testing without instruments or laboratory infrastructure.
Cardiopedia-Ligand: A ligand-receptor perturbation atlas of human cardiac organoid function and transcriptional state
Journal: Cell Stem Cell
Author: Janice D. Reid et al., Australia
Cardiopedia-Ligand maps how 87 ligands reshape cardiac organoid function and gene expression, uncovering disease-linked signaling patterns relevant to heart failure.
Histone H4 lysine 20 tri-methylation safeguards breast cancer lineage fidelity and unfolded protein response
Journal: Nature Communications
Author: Zheqi Li et al., USA
H4K20me3 emerges as a key epigenetic safeguard of breast cancer identity, revealing new therapeutic vulnerabilities in aggressive triple-negative tumors.
