Multi-stromal organoid co-culture modelling reveals epithelial–fibroblast heterogeneity in pancreatic cancer and pancreatitis
Journal: Nature Cell Biology
Author: Li, W., Jihad, M., Lloyd, E.G. et al., UK
Multi-stromal organoid co-cultures reveal disease-specific epithelial–fibroblast states in pancreatitis and pancreatic cancer, offering models to identify biomarkers and therapeutic vulnerabilities.
Creating bottom-up RNA transfer vehicles from synthetic protein assemblies
Journal: Nature
Author: Schuhmacher, M.K., Gruber, C., Lang, C.M.R. et al., Germany
AI-designed synthetic protein assemblies create programmable RNA delivery vehicles that outperform conventional carriers and enable gene-editing delivery across cellular and animal models.
3D epigenome of glial cell types in developing human cortex
Journal: Nature
Author: Jones, I.R., Wang, L., Kosicki, M. et al., USA
3D epigenomic mapping of developing human glia reveals cell-specific regulatory networks, prioritizes schizophrenia risk variants, and highlights human-specific programs in cortical development.
Scalable generation of T lymphocytes from human pluripotent stem cells in suspended organoids
Journal: Stem Cell Reports
Author: Lei Q, Miao Y, Zheng F et al., China
Rotating suspended artificial thymic organoids boost hPSC-derived T-cell production nearly 20-fold while preserving cytokine secretion, proliferation, cytotoxicity, and antitumor activity.
