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Intestinal organoid

Intestinal organoids from human intestinal tissue or iPSC has introduced an innovative method for recapitulating the complex structure and functions of human intestine.

The remarkable capacity of intestinal organoids to closely mimic human intestine significantly boosts their appeal to researchers focused on epithelial regeneration, adult stem cell biology, disease modeling, and cancer biology, extending their utility well beyond intestinal studies.

Intestinal organoid

€520+

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Lambda has developed organoid model for inflammatory diseases.
We offer inflammation organoid model associated with Inflammatory Bowel Disease-Leaky Gut modeling.

Cell Type

· ASC

Assay

· Leaky gut model
· Inflammatory bowel disease(3D)

€620+

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Fibrosis is a disease characterized by repetitive injury and inflammation.
Lambda provides a lung and intestine fibrosis organoid model, enabling drug development and efficacy assessment.

Cell Type

· iPSC

Assay

· Intestinal fibrosis model(3D)

€4.000+

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A more accurate assessment and monitoring of the efficacy of the microbiome can be achieved with an organoid model closely resembling the human intestine.

Cell Type

· iPSC

Assay

· Probiotic adhesion assay(2D)
· Host-Microbiome study(3D)

€4.000+

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Lambda provides drug absorption evaluation through drug (sample) permeability analysis
using hPSC-derived human functional intestinal epithelial cells (hIEC).

Cell Type

· iPSC

Assay

· Drug absorption assay (2D)

Experiment

Features

Our iPSC derived intestinal organoids acquire characteristics more akin to an adult intestine by undergoing maturation technology.

Generation process of mature human intestinal organoid (hIO)

We have developed highly functional organoids capable of long-term culture by applying our maturation technology to human intestinal organoids (hIO) derived from iPSCs.

Cellular and structural similarity

Our intestinal organoids arecomposed of cells that resemble those of a mature human intestine.

Immunofluorescent staining with a proliferation marker (Ki-67), an epithelial marker (ECAD) and mature intestinal markers (DEFA5, OLFM4, MUC13, and KRT20).

Functional similarity

Previous hIO

MaturehIO

Glucose-induced Ca2+ transients in real-time manner.
Mean values of peak fluorescence intensity by using Fluo-4-AM calcium indicator.

Representative images of the morphological changes after treatment with forskolin.