A more accurate assessment and monitoring of the efficacy of the microbiome can be achieved with an organoid model closely resembling the human intestine.
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Microbiome
Lambda offers highly human-mimicking intestinal organoids, enabling realistic research not only for long-term studies of the gastrointestinal system but also for more lifelike investigations into the interactions between cells and microorganisms.
This platform is versatile, serving as a valuable tool for drug development and disease research.
Cell Type
· ASC
Organoid type
· Intestinal organoid
Lambda provides a 2D platform for gut attachment and allows for the evaluation of probiotics efficacy through gut attachment analysis.
Cell Type
· iPSC
Organoid type
· Intestinal organoid
Host-Microbiome Study focuses on studying the interaction between humans and microorganisms, utilizing organoid systems to process probiotics and analyze the metabolic activities of microbes.
It provides discovery and analysis of metabolites that interact with the functions of different organs.
Lambda offers highly human-mimicking intestinal organoids, enabling realistic research not only for long-term studies of the gastrointestinal system but also for more lifelike investigations into the interactions between cells and microorganisms.
This platform is versatile, serving as a valuable tool for drug development and disease research.
The evaluation of barrier permeability also demonstrates that probiotics can pass through the intestinal barrier. It can be observed within the intestinal organoids after 24 hours.
When comparing the group treated with LPS alone and the group treated with Lactobacillus, occludin and ZO-1 expression were weakened in the group treated with LPS alone, showing damage to the tight junction.
However, the group treated with LPS and Lactobacillus simultaneously did not differ significantly from the control group.
This suggests that Lactobacillus may alleviate the negative effects caused by treatment with LPS alone and may play a role in protecting the tight junction of the intestine under inflammatory conditions.
Lambda Biologics GmbH
Deutscher Pl. 5c, 04103 Leipzig, Germany
